CM-Glucan Granulate
The repair and defense molecule
CM-Glucan Granulate is a derivative of ß-(1,3) and ß-(1,6) glucan, a natural yeast polysaccharide featuring immune-stimulating properties. ß-Glucan that is isolated from yeast is insoluble in water and therefore not suitable for topical use. Consequently, Mibelle Biochemistry has developed a process to offer CM-Glucan Granulate, a biologically active ß-glucan derivative that maintains the same biological activity as ß-glucan, is highly purified and also water-soluble.
Numerous clinical studies have demonstrated the benefits of CM-Glucan Granulate on either very extremely sensitive skin or skin that is exposed to extreme stress, e.g. following esthetic procedures.
ß-(1-3)-glucan purified from the cell walls of common baker’s yeast is a physiologically active compound. It fights infections and is probably one of the most studied natural immunomodulators.
Mibelle Biochemistry has been a pioneer in terms of purifying ß-glucans from the cell walls of baker’s yeast and in modifying the molecule for an improved water-solubility.
In vitro
- Inhibits the release of CGRP (->soothing effect)
- Inhibits calcium influx into sensory neurons (->soothing effect)
In vivo
- Strongly protects skin against dehydration after stress
- Accelerates skin regeneration
- Protects against UV-induced loss of firmness
- Protects skin lipids against UV damage
- Reduces wrinkle depth
Carboxymethylated beta-(1-3)-Glucan (C&T, 1996)
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CM-Glucan A Biological Response Modifier from Baker's Yeast for Skin Care SOEFW 8 1997
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CM-Glucan a New Yeast Polysaccharide for Cosmetic Use (C&TMWW1994)
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Improving skin function with CM-Glucan, a biological response modifier from yeast (Int. J. of Cosmetic Science, 1998)
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Photoprotective Effects of CM-Glucan on cultured human skin cells_Euro Cosm, 1995
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Pretreatment of skin with Ginko biloba extract_Contact Dermatitis1998
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